کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4282625 1611760 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GPC-1 may serve as a predictor of perineural invasion and a prognosticator of survival in pancreatic cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
GPC-1 may serve as a predictor of perineural invasion and a prognosticator of survival in pancreatic cancer
چکیده انگلیسی

SummaryObjectiveThe purpose of this study was to investigate the expression of glial cell derived neurotrophic factor (GDNF), glypican-1 (GPC-1), and matrix metalloproteinase-9 (MMP-9), and their association with clinicopathologic characteristics as well as prognostic significance in pancreatic cancer.MethodsImmunohistochemical assessment of GDNF, GPC-1, and MMP-9 was performed in 62 cases of surgically resected pancreatic cancer. Perineural invasion in pancreatic cancer was observed by marking nerve fiber with S-100, while 16 normal pancreatic tissues were used as normal control. Correlations of GDNF, GPC-1 and MMP-9 expressions with clinicopathologic parameters were analyzed. A survival analysis was performed to find the prognostic significance.ResultsThe expressions of GDNF, GPC-1 and MMP-9 in pancreatic cancer tissue were significantly higher than of those in normal pancreatic tissues (41/62 vs. 5/16 for GDNF, 35/62 vs. 2/16 for GPC-1, and 37/62 vs. 3/16 for MMP-9; p < 0.01, respectively). The overexpression of GDNF, GPC-1, and MMP-9 in pancreatic cancer tissue was significantly related to the perineural invasion (p < 0.05). Although the overexpression of these genes was related to poor survival, GPC-1 had an independent prognostic effect on overall survival.ConclusionGPC-1 is significantly related to the perineural invasion of pancreatic cancer, holding some prognostic significance in patients with pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Surgery - Volume 36, Issue 1, January 2013, Pages 7–12
نویسندگان
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