کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4282786 1611752 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dexamethasone combined with other antiemetics for prophylaxis after laparoscopic cholecystectomy
ترجمه فارسی عنوان
دگزامتازون همراه با سایر داروهای ضد عفونی برای پیشگیری پس از کولسیستکتومی لاپاروسکوپی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

SummaryBackground/ObjectivePostoperative nausea and vomiting (PONV) is one of the most common and distressing adverse events after laparoscopic cholecystectomy (LC). A meta-analysis of randomized clinical trials (RCTs) was performed to determine the efficacy and safety of dexamethasone combined with other antiemetic in the prevention of PONV in patients undergoing LC.MethodsA systematic literature search was conducted to identify all relevant RCTs. The primary outcome was PONV in the early period (0–3 hours, 0–4 hours, or 0–6 hours), late period (>6 hours), and the overall period (0–24 hours).ResultsNine RCTs with a total of 1089 patients were included in the analysis. Pooled analysis showed that dexamethasone combined with other antiemetics provided significantly better prophylaxis than single antiemetics in the early period [odds ratio (OR): 0.34; 95% confidence interval (CI): 0.21–0.55; p < 0.001], late period (OR: 0.35; 95% CI: 0.22–0.57; p < 0.001), and the overall period (OR: 0.36; 95% CI: 0.27–0.49; p < 0.001). Correspondingly, rescue antiemetic usage was significantly less in the combination therapy group (OR: 0.22; 95% CI: 0.12–0.41; p < 0.001). The most frequently reported adverse events were headache, dizziness, and itching. The incidence of adverse events did not differ between the two groups.ConclusionDexamethasone combined with other antiemetics was significantly better than single antiemetics for prophylaxis of PONV in patients undergoing LC, without apparent side effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Surgery - Volume 38, Issue 1, January 2015, Pages 21–27
نویسندگان
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