Giant condyloma acuminatum of penis with cancer transformation

SummaryGiant condyloma acuminatum (GCA) is a rare, sexually transmitted disease with a high rate of local recurrence and malignant transformation. However, the optimal treatment for patients in whom GCA coexists with penile cancer is not well defined. We report a case treated successfully with preservation of the penis. Wide tumor excision was performed and the patient received adjuvant intra-arterial chemotherapy with methotrexate. We also evaluate the efficacy and functional outcome of penile preservation management for GCA with penile cancer transformation. In the present case, no recurrence of penile tumor or of condyloma was noted during follow-up for more than 12 months after treatment. The patient is very satisfied with the cosmetic and functional results following preservation of the penis.