کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4285317 1611953 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Limited effectiveness of patent blue dye in addition to isotope scanning for identification of sentinel lymph nodes: Cross-sectional real-life study in 1024 breast cancer patients
ترجمه فارسی عنوان
اثربخشی محدودی از رنگ آبی رنگرزی علاوه بر اسکن ایزوتوپ برای شناسایی گره های لنفاوی حوادث: مقیاس واقعی زندگی در 1024 بیمار مبتلا به سرطان پستان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


• Blue dye and radioisotope SLN mapping in 1024 BC pts.
• Limited blue dye effectiveness.
• Use of PBD should be avoided when a radioisotope mapping agent is available.

BackgroundAlthough morbidity is reduced when sentinel lymph node (SLN) biopsy is performed with dual isotopic and blue dye identification, the effectiveness of adding blue dye to radioisotope remains debated because side effects including anaphylactic reactions.Patients and MethodsUsing data from a prospectively maintained database, 1884 lymph node-negative breast cancer patients who underwent partial mastectomy with SLN mapping by a dual-tracer using patent blue dye (PBD) and radioisotope were retrospectively studied between January 2000 and July 2013. Patients with tumors <3 cm and with >1 node detected by one of the two techniques (N = 1024) were included in this real-life cross-sectional study.ResultsAmong the 1024 patients, 274 had positive SLN detected by isotopic and/or PBD staining. Only 4 patients having no detectable radioactivity in the axilla had SLN identified only by PBD staining (blue-only) while 26 patients had SLN only identified by isotopic detection (hot-only) illustrating failure rates of 9.5% (26/274) and 1.5% (4/274), respectively. Among these four patients, two had negative lymphoscintigraphy. Therefore, the contribution of PBD to metastatic nodes identification was relevant for only 2/274 patients (0.8%). Three patients (0.3%) had an allergic reaction with PBD, and anaphylactic shock occurred in two cases (0.2%).ConclusionsThe added-value of PBD to reduce the false-negative rate of SLN mapping is only limited to the rare cases in which no radioactivity is detectable in the axilla (<1%). When a radioisotope mapping agent is available, the use of PBD should be avoided, because it can induce anaphylaxis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 33, Part A, September 2016, Pages 177–181
نویسندگان
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