کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4287589 | 1612047 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Early prediction of anastomotic leakage after colorectal surgery by measuring peritoneal cytokines: Prospective study Early prediction of anastomotic leakage after colorectal surgery by measuring peritoneal cytokines: Prospective study](/preview/png/4287589.png)
BackgroundAnastomotic leakage (AL) is a major cause of postoperative mortality and morbidity in colorectal surgery. We investigated the early prediction of peritoneal cytokine levels in developing AL after colorectal surgery.MethodsThirty-four patients with colorectal carcinoma, who underwent elective surgery, were included prospectively. Peritoneal samples were collected on the fifth postoperative day and interleukin (IL)-6, IL-10 and tumor necrosis factor-α were measured. Patients were divided into two groups: those with clinical evidence of AL (group 1) and those without any evidence of AL (group 2).ResultsOf the 34 patients undergoing anastomoses, clinically evident AL occurred in 4 patients (11.7%). There was a positive correlation between AL and peritoneal cytokine levels and blood loss and operation time and hospital stay. Peritoneal cytokine levels were significantly higher in group 1 as compared to group 2. The significant increase in patients with AL was observed between peritoneal cytokine levels and the postoperative days. However, a significant decrease in patients without AL was observed.ConclusionThe peritoneal cytokine levels can be an additional diagnostic tool that can support the early prediction of AL in colorectal surgery.
Journal: International Journal of Surgery - Volume 6, Issue 1, February 2008, Pages 28–35