کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4289224 1612112 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complete pathological response to Imatinib mesylate in an extraintestinal gastrointestinal stromal tumor
ترجمه فارسی عنوان
واکنش پاتولوژیک کامل به متیلات ماتیتیینب در یک تومور استرومائی گوارشی فوقالعاده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

INTRODUCTIONGastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the digestive tract. Extraintestinal locations (EGIST) have been described showing similar pattern of immunohistochemical markers than GIST. Inhibitors of tyrosine kinases such as Imatinib or Sunitinib are the mainstay treatment in the management of advanced or metastatic GIST. Complete pathological response to these agents is an extremely rare event, especially in the case of EGIST due to its more aggressive behavior reported.PRESENTATION OF CASEHere we describe the case of a 61 years old woman, with an advanced GIST, who was operated after 10 months of Imatinib mesylate. The biopsy demonstrated the extra intestinal location of the tumor and a complete pathological response was confirmed.DISCUSSIONComplete pathological response to Imatinib is a rare event. To our knowledge, this is the first report of complete response in an EGIST. New clinical, radiological and metabolic criteria of tumoral response to neoadjuvant treatment are revised.CONCLUSIONEGIST complete pathological response to Imatinib can be achieved. However, recommendation of systematic neoadjuvant therapy with Imatinib remains investigational and more studies are warranted in the future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery Case Reports - Volume 5, Issue 10, 2014, Pages 681–685
نویسندگان
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