کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4290594 1612205 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Composite Skin Grafting with Human Acellular Dermal Matrix Scaffold for Treatment of Diabetic Foot Ulcers: A Randomized Controlled Trial
ترجمه فارسی عنوان
پیوند کامپوزیت پوست با داربست ماتریکس پوستی انسانی برای درمان زخم های پا دیابتی: یک آزمایش تصادفی کنترل شده
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

BackgroundComposite split-thickness skin grafting (STSG) with acellular dermal matrix (ADM) has been used successfully in burn injuries and trauma, but its use in treating diabetic foot ulcers (DFUs) has not been reported to date. This study investigated the efficacy and safety of composite STSG with ADM in the treatment of DFUs.Study DesignFifty-two patients with DFUs were randomized into experimental and control groups. Patients in the experimental group received composite STSG over ADM; the control group received STSG alone. The primary end point was recurrence rate 12 months after grafting. Secondary end points were the healing quality of the grafted site according to Manchester Scar Scale and complete wound closure and complication rates.ResultsThe number of patients that experienced recurrence was significantly less in the experimental group compared with the control group (4.3% vs 22.7%; p = 0.02). The autografted sites of the experimental group had better appearance and lower Manchester Scar Scale scores (median 9 [interquartile range 8 to 10.25] vs median 11 [interquartile range 10 to 12]; p = 0.006). Rates of complete wound closure by weeks 2, 4, and 8 were similar, as were the rates of complications by post-grafting week 4 (38.5% vs 26.9%; p = 0.38).ConclusionsComposite STSG over an ADM scaffold provides an effective method to treat DFUs, with lower recurrence rates and better physical attributes compared with the traditional STSG method. Complete wound closure and complication rates were comparable between these methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Surgeons - Volume 222, Issue 6, June 2016, Pages 1171–1179
نویسندگان
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