کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4297254 | 1288252 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CO2 Abdominal Insufflation Pretreatment Increases Survival After a Lipopolysaccharide-Contaminated Laparotomy
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
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چکیده انگلیسی
Carbon dioxide (CO2)-pneumoperitoneum is known to favorably modify the systemic immune response during laparoscopic surgery. The presented studies were designed to determine whether treating animals with CO2 abdominal insufflation before undergoing a lipopolysaccharide (LPS)-contaminated laparotomy would serve as “shock prophylaxis” and thus improve survival and attenuate cytokine production. Rats were randomized into five groups: CO2-pneumoperitoneum, helium-pneumoperitoneum, anesthesia control, laparotomy/LPS control, and LPS only control. Animals in the first four groups all received a laparotomy and a lethal dose of LPS. Immediately preceding their laparotomy, animals in the pneumoperitoneum groups received a 30-minute pretreatment of abdominal insufflation with either CO2 or helium. The anesthesia control group received a 30-minute pretreatment of isoflurane. Animal mortality was then recorded during the ensuing 72 hours. Subsequently, a similar protocol was repeated for measurements of cytokines. CO2-pneumoperitoneum increased survival at 48 hours compared with LPS control (P <.05), and decreased interleukin-6 plasma levels at 2 hours (P <.05). Abdominal insufflation with CO2 before the performance of a laparotomy contaminated with endotoxin increases survival and attenuates interleukin-6. The beneficial immune-modulating effects of CO2-pneumoperitoneum endure after abdominal insufflation. CO2-pneumoperitoneum pretreatment may improve outcomes among patients undergoing gastrointestinal surgery who are at high risk for abdominal fecal contamination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Gastrointestinal Surgery - Volume 10, Issue 1, 1 January 2006, Pages 32-38
Journal: Journal of Gastrointestinal Surgery - Volume 10, Issue 1, 1 January 2006, Pages 32-38
نویسندگان
Joseph M. M.D., Eric J. M.D., Alexander R. M.D., Antonio Ph.D., Samuel P. M.D., Michael R. D.O., Mark A. M.D.,