کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4302312 | 1288454 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Postoperative Serum Concentrations of High Mobility Group Box Chromosomal Protein-1 Correlates to the Duration of SIRS and Pulmonary Dysfunction Following Gastrointestinal Surgery Postoperative Serum Concentrations of High Mobility Group Box Chromosomal Protein-1 Correlates to the Duration of SIRS and Pulmonary Dysfunction Following Gastrointestinal Surgery](/preview/png/4302312.png)
ObjectiveTo clarify the time course of changes in the serum HMGB-1 concentrations in patients undergoing major gastrointestinal surgery, and to investigate whether the serum HMGB-1 levels correlate with the postoperative clinical course of the patients.MethodsTwenty-eight patients with alimentary tract carcinoma who underwent elective gastrointestinal surgery were enrolled in this study. The correlation between the serum HMGB-1 levels and the postoperative clinical course were evaluated.ResultsSerum HMGB-1 concentrations in patients who underwent surgery for gastrointestinal cancer increased gradually during postoperative days, and reached peak concentrations on postoperative day 3 (POD3). There was a statistically significant positive correlation between the serum HMGB-1 levels on POD3 or POD5 and the duration of SIRS (r = 0.68, P < 0.001, r = 0.45, P < 0.05, respectively). A significantly positive correlation was found between the serum HMGB-1 levels on POD3 or POD5 and the heart rates on POD3 or POD5. Furthermore, there was a negative correlation between the serum HMGB-1 levels and PaO2/FiO2 ratio on POD3.ConclusionsSerum HMGB-1 levels increase after major gastrointestinal surgery, and the serum peak HMGB-1 levels correlate with the duration of SIRS and postoperative pulmonary dysfunction.
Journal: Journal of Surgical Research - Volume 170, Issue 1, September 2011, Pages e135–e140