کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4302510 | 1288458 | 2011 | 4 صفحه PDF | دانلود رایگان |
BackgroundThe density of tumor-infiltrating lymphocytes (TIL) in lung cancer is variable and may have an impact on disease course. We reviewed the histology of lobectomy specimens from patients with pathologic stage IA-IB non-small-cell lung cancer to determine the impact of TILs on recurrence and survival.Materials and methodsTwo hundred nineteen lobectomies performed between 2002 and 2005 for stage IA-IB non-small-cell lung cancer were reviewed. Patients were stratified according to tumor size. Infiltrating patterns were graded as follows: group 1 (none to mild infiltrate) or group 2 (moderate to severe infiltrate). Recurrence rates and disease-free survival were compared between groups in each tumor size cohort.ResultsA higher density of TILs was associated with lower disease recurrence (60%, group 1 versus 21%, group 2, P = 0.02) and improved 5-y disease-free survival (35.9%, group 1 versus 75.6%, group 2, P = 0.04) in patients with tumors 5cm or greater in diameter. There were no correlations in patients with smaller tumors.ConclusionsA higher degree of TILs within large node-negative non-small-cell lung cancer correlates with decreased risk of disease recurrence and improved disease-free survival. This subset of patients with tumor infiltration needs to be examined more closely with regards to outcomes of adjuvant chemotherapy.
Journal: Journal of Surgical Research - Volume 167, Issue 2, 15 May 2011, Pages 207–210