کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4302606 1288459 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mast Cell Degranulation is Essential for Anastomotic Healing in Well Perfused and Poorly Perfused Rat Colon
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Mast Cell Degranulation is Essential for Anastomotic Healing in Well Perfused and Poorly Perfused Rat Colon
چکیده انگلیسی

BackgroundMast cell degranulation is an important step in early wound healing in the skin however the role of the mast cell in anastomotic healing is less clear. The aim of this study was to investigate the importance of mast cell degranulation in anastomotic healing and to assess whether a promoter of mast cell degranulation could increase anastomotic healing in poorly perfused bowel.MethodsFifty Wistar rats were divided into five groups: control, normally perfused bowel with mast cell stabilisation, normally perfused bowel with mast cell degranulation, hypoperfused bowel, and hypoperfused bowel with mast cell degranulation. A colo-colonic anastomosis was formed in each animal. Four d later, following sacrifice, the strength of the anastomosis was assessed in each animal.ResultsMast cell stabilisation reduced anastomotic healing in normally perfused bowel (P < 0.001). Hypoperfused bowel resulted in reduced anastomotic strength (P < 0.001) however the addition of a mast cell degranulating agent increased healing in hypoperfused bowel to levels comparable with control.ConclusionsMast cell degranulation is essential for early anastomotic healing. Healing is reduced in hypoperfused bowel but the administration of a mast cell degranulation agent can compensate for the adverse effects of a poor blood supply on anastomotic healing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 164, Issue 1, November 2010, Pages e73–e76
نویسندگان
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