کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4303814 | 1288487 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mesenteric Lymphatic Ducts Ligation Decreases the Degree of Gut-Induced Lung Injury in a Portal Vein Occlusion and Reperfusion Canine Model Mesenteric Lymphatic Ducts Ligation Decreases the Degree of Gut-Induced Lung Injury in a Portal Vein Occlusion and Reperfusion Canine Model](/preview/png/4303814.png)
BackgroundWhether the mesenteric lymphatic system could serve as a route of transport by which gut-derived inflammatory mediators contribute to the induction of remote organ injuries is uncertain. We therefore made a gut-induced lung injury canine model by portal vein occlusion and reperfusion (PV O/R) and studied the role of mesenteric lymphatic ducts ligation (ML) to gut-induced lung injury with this model.Material and methodsEighteen mongrel dogs were divided into control, PV O/R, and PV O/R + ML groups. Cytokines and endotoxin levels in the portal vein and lymph from thoracic duct in different groups were tested. The permeability, myeloperoxidase activity, and histopathological investigation of intestine and lung were evaluated.ResultsCytokines and endotoxin levels in the portal vein were significantly increased in experimental groups compared with control group (P < 0.05), and that in the lymph from thoracic duct were significantly increased in PV O/R group compared with control and PV O/R + ML group (P < 0.05). Lung permeability and MPO activity in PV O/R group were significantly higher than those in control and PV O/R + ML group (P < 0.05); intestinal permeability in experimental groups were significantly higher with respect to control group. The lung injury score in PV O/R group was significantly higher than those in control and PV O/R + ML group (P < 0.05) and the intestinal injury scores in experimental groups were significantly higher than control group (P < 0.05).ConclusionsThe gut-induced lung injury canine model made by PV O/R is successful, and mesenteric lymphatic ducts ligation decreases the degree of gut-induced lung injury in this model.
Journal: Journal of Surgical Research - Volume 154, Issue 1, 1 June 2009, Pages 45–50