کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4304128 1288497 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Shock Wave Therapy for Acute and Chronic Soft Tissue Wounds: A Feasibility Study 1
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Shock Wave Therapy for Acute and Chronic Soft Tissue Wounds: A Feasibility Study 1
چکیده انگلیسی

BackgroundNonhealing wounds are a major, functionally-limiting medical problem impairing quality of life for millions of people each year. Various studies report complete wound epithelialization of 48 to 56% over 30 to 65 d with different treatment modalities including ultrasound, topical rPDGF-BB, and composite acellular matrix. This is in contrast to comparison control patients treated with standard wound care, demonstrating complete epithelialization rates of 25 to 39%. Extracorporeal shock wave therapy (ESWT) may accelerate and improve wound repair. This study assesses the feasibility and safety of ESWT for acute and chronic soft-tissue wounds.Study designTwo hundred and eight patients with complicated, nonhealing, acute and chronic soft-tissue wounds were prospectively enrolled onto this trial between August 2004 and June 2006. Treatment consisted of debridement, outpatient ESWT [100 to 1000 shocks/cm2 at 0.1 mJ/mm2, according to wound size, every 1 to 2 wk over mean three treatments], and moist dressings.ResultsThirty-two (15.4%) patients dropped out of the study following first ESWT and were analyzed on an intent-to-treat basis as incomplete healing. Of 208 patients enrolled, 156 (75%) had 100% wound epithelialization. During mean follow-up period of 44 d, there was no treatment-related toxicity, infection, or deterioration of any ESWT-treated wound. Intent-to-treat multivariate analysis identified age (P = 0.01), wound size ≤10 cm2 (P = 0.01; OR = 0.36; 95% CI, 0.16 to 0.80), and duration ≤1 mo (P < 0.001; OR = 0.25; 95% CI, 0.11 to 0.55) as independent predictors of complete healing.ConclusionsThe ESWT strategy is feasible and well tolerated by patients with acute and chronic soft tissue wounds. Shock wave therapy is being evaluated in a Phase III trial for acute traumatic wounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 143, Issue 1, November 2007, Pages 1–12
نویسندگان
, , , , , , , , , ,