Methylprednisolone Fails to Preserve Pulmonary Surfactant and Blood-Air Barrier Integrity in a Porcine Cardiopulmonary Bypass Model

Despite reduction of the systemic inflammatory response and pulmonary TNF-α generation, methylprednisolone fails to decrease pulmonary TNF-α and to preserve pulmonary surfactant morphology, blood-air barrier integrity, and pulmonary function after CPB.