Paclitaxel Interrupts TGF-β1 Signaling Between Gallbladder Epithelial Cells and Myofibroblasts

These findings support a model in which GBEC communicate with subepithelial GBMF via TGF-β1, leading to collagen deposition and fibrosis, and in which GBMF possess autocrine mechanisms involving TGF-β1 that could regulate collagen production. PT inhibits these fibrogenic pathways.