کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4305057 | 1288523 | 2006 | 6 صفحه PDF | دانلود رایگان |
BackgroundWe previously observed increased serum diamine oxidase activity during clinical cardiopulmonary bypass, indicating small intestinal mucosal ischemia followed by bacterial translocation.Materials and methodsIn seven female rabbits undergoing cardiopulmonary bypass for 1 h, we analyzed the localization of diamine oxidase immunohistochemically, and measured its activity in serum and abdominal organs before and after cardiopulmonary bypass (CPB).ResultsPreoperatively, diamine oxidase activity and immunoreactivity were high in the small intestine, localized to villus tips. Serum activity increased significantly after CPB, whereas small intestinal diamine oxidase decreased with mucosal injury.ConclusionsIn this model serum diamine oxidase activity appeared to reflect CPB induced intestinal mucosal injury.
Journal: Journal of Surgical Research - Volume 131, Issue 1, March 2006, Pages 58–63