کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4308129 | 1289270 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands](/preview/png/4308129.png)
چکیده انگلیسی
One major barrier in the development of pancreas cancer therapeutics is the selective delivery of the drugs to their cellular targets. We have previously developed several sigma-2 ligands and reported the discovery of a component of the receptor for these ligands. Several sigma-2 ligands have been shown to trigger apoptosis in pancreas cancer cells. More importantly, sigma-2 ligands are internalized rapidly by the cancer cells and are capable of delivering other small-molecule therapeutics. Here we review sigma-2 ligands and conjugates as a potential novel therapy suitable for investigation in patients with pancreatic cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgery - Volume 152, Issue 3, Supplement, September 2012, Pages S152–S156
Journal: Surgery - Volume 152, Issue 3, Supplement, September 2012, Pages S152–S156
نویسندگان
John R. Hornick, Dirk Spitzer, Peter Goedegebuure, Robert H. Mach, William G. Hawkins,