کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4312205 1612933 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sensitivity during the forced swim test is a key factor in evaluating the antidepressant effects of abscisic acid in mice
ترجمه فارسی عنوان
حساسیت در طی آزمون شناور اجباری عامل اصلی در ارزیابی اثرات ضد افسردگی اسید واکنشگر در موش است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• FST sensitive and insensitive mice were screened out based on the FS pre-test.
• ABA showed antidepressant-like effects in FST sensitive mice but not insensitive.
• The two substrains mice performed differently during forced swimming.

Abscisic acid (ABA), a crucial phytohormone, is distributed in the brains of mammals and has been shown to have antidepressant effects in the chronic unpredictable mild stress test. The forced swim test (FST) is another animal model that can be used to assess antidepressant-like behavior in rodents. Here, we report that the antidepressant effects of ABA are associated with sensitivities to the FST in mice. Based on mean immobility in the 5-min forced swim pre-test, ICR mice were divided into short immobility mice (SIM) and long immobility mice (LIM) substrains. FST was carried out 8 days after drug administration. Learned helplessness, as shown by increased immobility, was only observed in SIM substrain and could be prevented by an 8-day ABA treatment. Our results show that ABA has antidepressant effects in SIM substrain and suggest that mice with learned helplessness might be more suitable for screening potential antidepressant drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 300, 1 March 2016, Pages 106–113
نویسندگان
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