کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4312485 1612949 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An ecologically relevant guinea pig model of fetal behavior
ترجمه فارسی عنوان
یک مدل خوک جالب توجه از نظر جنین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• IAF hairless guinea pigs were acclimated to ultrasound procedures without restraint.
• Behavior of fetal offspring was observed weekly across gestation.
• No elevation of cortisol was observed during procedures with pregnant females.
• Fetal development of movement coordination was similar to other species studied.
• Fetal behavior may be useful in the study of prenatal origins of disability.

The laboratory guinea pig, Cavia porcellus, shares with humans many similarities during pregnancy and prenatal development, including precocial offspring and social dependence. These similarities suggest the guinea pig as a promising model of fetal behavioral development as well. Using innovative methods of behavioral acclimation, fetal offspring of female IAF hairless guinea pigs time mated to NIH multicolored Hartley males were observed longitudinally without restraint using noninvasive ultrasound at weekly intervals across the 10 week gestation. To ensure that the ultrasound procedure did not cause significant stress, salivary cortisol was collected both before and after each observation. Measures of fetal spontaneous movement and behavioral state were quantified from video recordings from week 3 through the last week before birth. Results from prenatal quantification of Interlimb Movement Synchrony and state organization reveal guinea pig fetal development to be strikingly similar to that previously reported for other rodents and preterm human infants. Salivary cortisol readings taken before and after sonography did not differ at any observation time point. These results suggest this model holds translational promise for studying the prenatal mechanisms of neurobehavioral development, including those that may result from adverse events. Because the guinea pig is a highly social mammal with a wide range of socially oriented vocalizations, this model may also have utility for studying the prenatal origins and trajectories of developmental disabilities with social-emotional components, such as autism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 283, 15 April 2015, Pages 175–183
نویسندگان
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