Systemic or intra-prelimbic cortex infusion of prazosin impairs fear memory reconsolidation

► Post-retrieval infusion of prazosin impairs subsequent retrieval of fear memory. ► Impairment in fear memory induced by prazosin is dependent of memory reactivation. ► Impairment in fear memory induced by prazosin does not spontaneously recover with time. ► Intra-prelimbic cortex infusion of prazosin impairs fear memory reconsolidation.