کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4312785 | 1612989 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice](/preview/png/4312785.png)
The APOE-ɛ4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-ɛ4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-ɛ4 on cognitive functions.
► Young hAPP-Yac/ApoE4-TR mice outperform hAPP-Yac/ApoE3-TR mice on spatial learning.
► Young hAPP-Yac/ApoE4-TR mice outperform hAPP-Yac/ApoE3-TR mice on spatial memory.
► No difference between both mouse lines in the non-spatial version of the task.
Journal: Behavioural Brain Research - Volume 243, 15 April 2013, Pages 1–5