Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice

► CSB6B, a VGLUTs inhibitor, attenuated acute METH-induced hyperactivity. ► CSB6B attenuated development of METH-induced behavioral sensitization. ► CSB6B attenuated expression of behavioral sensitization to METH. ► VGLUTs were involved in METH dependence. ► VGLUTs may be a new target against METH dependence.