کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313129 1289986 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Behavioral effects of environmental enrichment during gestation in WKY and Wistar rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Behavioral effects of environmental enrichment during gestation in WKY and Wistar rats
چکیده انگلیسی

Effects of prenatal environmental enrichment (EE) were examined in Wistar Kyoto (WKY) “depressive- and anxious-like” rats and Wistar rats. During gestation, dams lived in standard cages or in EE cages. Their behavior during gestation and lactation was observed. On weaning day, they were tested in the forced swimming test, and corticosterone concentration was measured from their plasma. The offspring, reared in standard environment, were tested as juveniles or young adults in the elevated plus maze, open field and forced swimming tests. Corticosterone concentration in feces was analyzed. EE offspring showed more anxiety-like behaviors and less activity, compared to controls. Effects were more prominent in youth than in adulthood and in Wistar rats more than in WKY. EE lowered corticosterone concentration in young WKY rats’ feces. EE induced changes in the dams’ behavior during gestation and lactation. These changes in dams’ behavior could be mediators of the effects on the offspring.


► Wistar and Wistar Kyoto pregnant dams lived in standard or enriched cages.
► EE induced changes in the dams’ behavior during gestation and lactation.
► In offspring, EE decreased activity and increased anxiety-like behaviors.
► In offspring, effects were more prominent at youth and in Wistar rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 233, Issue 2, 1 August 2012, Pages 245–255
نویسندگان
, ,