کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4313385 | 1289995 | 2012 | 6 صفحه PDF | دانلود رایگان |

The aim of this study was to determine the role of the endogenous dynorphin/kappa opioid receptor (DYN/KOP) system in ethanol-induced state-dependent conditioned place preference (CPP). To this end, mice lacking the pro-DYN gene and their wild-type littermates/controls were tested for baseline place preference on day 1, received 15-min morning and afternoon conditionings with saline or ethanol (2 g/kg) each day for three consecutive days and were then tested for CPP under a drug-free state on day 5 and following a saline or ethanol (1 or 2 g/kg) challenge on day 8. Given that compensatory developmental changes may occur in knockout mice, the effect of nor-binaltorphimine (nor-BNI), a KOP antagonist, on state-dependent CPP induced by ethanol was also studied in wild-type mice. On day 1, mice were tested for baseline place preference and, 4 h later, treated with saline or nor-BNI (10 mg/kg). On days 2–4, mice received 15-min morning and afternoon conditionings and were tested for CPP under a drug-free state on day 5 and following an ethanol (1 g/kg) challenge on day 8. A comparable CPP was observed in mice lacking the pro-DYN gene and their wild-type littermates/controls as well as in wild-type mice treated with nor-BNI and their saline-treated controls. However, these mice compared to their respective controls exhibited a greater CPP response following an ethanol (1 g/kg) challenge, suggesting that the endogenous DYN/KOP system may negatively regulate ethanol-induced state-dependent CPP.
► The role of endogenous dynorphin was tested in ethanol-induced state-dependent CPP.
► Ethanol-induced state-dependent CPP was enhanced in dynorphin null mice compared to their wild-type littermates.
► Ethanol-induced state-dependent CPP was also increased by nor-BNI, a kappa antagonist.
► These results suggest that dynorphin may regulate ethanol-induced state-dependent CPP.
Journal: Behavioural Brain Research - Volume 227, Issue 1, 1 February 2012, Pages 58–63