کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313481 1289998 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice
چکیده انگلیسی

In the current study, administration of poly I:C induced a deficit in contextual, but not auditory-cue, fear memory consolidation. This memory deficit coincided with a decrease in hippocampal and cortical BDNF mRNA expression. These results extend prior work, and suggest that a single peripheral injection of poly I:C disrupts contextual fear memory consolidation processes in adult mice, and that these deficits may potentially be mediated by diminished BDNF expression.


► Poly I:C administration leads to contextual, but not auditory-cue, fear memory consolidation deficits.
► These deficits cannot be attributed to sickness behavior.
► Decreased BDNF mRNA was observed in the hippocampus and parietal cortex.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 228, Issue 2, 17 March 2012, Pages 452–457
نویسندگان
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