کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4313711 | 1290006 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats when the injection was given immediately, but not 6 h after training. NaB had no effect in younger rats with normal memory retention. The results indicate that HDACis can ameliorate aging-related memory impairments by influencing the early consolidation phase of memory formation.
► Sodium butyrate ameliorated an aging-associated recognition memory deficit in rats.
► The memory-improving effect was produced by an injection given early after training.
► Histone deacetylase inhibitors can act on consolidation to rescue memory dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 221, Issue 1, 1 August 2011, Pages 329–332
Journal: Behavioural Brain Research - Volume 221, Issue 1, 1 August 2011, Pages 329–332
نویسندگان
Gustavo K. Reolon, Natasha Maurmann, Aline Werenicz, Vanessa A. Garcia, Nadja Schröder, Marcelo A. Wood, Rafael Roesler,