Serotonergic involvement in methamphetamine-induced locomotor activity: A detailed pharmacological study

► We assessed serotonergic and dopaminergic effects on the methamphetamine-induced hyperactivity. ► Modulation was observed by 5-HT depletion, certain 5-HT receptor ligands and dopamine ligands. ► Data suggest key 5-HT involvement with potential downstream dopamine involvement.