کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313826 1290011 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex
چکیده انگلیسی

We show that in naïve mice, tonic currents mediated by δ subunit-containing GABAA receptors in fast spiking interneurons are larger in females than in males while in regular spiking neurons such a difference was not observed. Moreover, in fast spiking interneurons, associative learning induced a larger reduction of these currents in females than in males. In contrast, in regular spiking neurons, learning similarly enhanced tonic currents in both sexes.

Research highlights
► Learning alters intrinsic tonic currents in cell type-specific manner irrespective of sex.
► In FS neurons from naïve mice, THIP induces larger tonic current in females.
► In FS cells, learning-induced changes in tonic current are larger in females.
► Input resistance is correlated with endogenous tonic current irrespective of sex.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 219, Issue 2, 1 June 2011, Pages 373–377
نویسندگان
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