کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4313826 | 1290011 | 2011 | 5 صفحه PDF | دانلود رایگان |
We show that in naïve mice, tonic currents mediated by δ subunit-containing GABAA receptors in fast spiking interneurons are larger in females than in males while in regular spiking neurons such a difference was not observed. Moreover, in fast spiking interneurons, associative learning induced a larger reduction of these currents in females than in males. In contrast, in regular spiking neurons, learning similarly enhanced tonic currents in both sexes.
Research highlights
► Learning alters intrinsic tonic currents in cell type-specific manner irrespective of sex.
► In FS neurons from naïve mice, THIP induces larger tonic current in females.
► In FS cells, learning-induced changes in tonic current are larger in females.
► Input resistance is correlated with endogenous tonic current irrespective of sex.
Journal: Behavioural Brain Research - Volume 219, Issue 2, 1 June 2011, Pages 373–377