d-Cycloserine in prelimbic cortex enhances relearning of an odor-reward associative task

We investigated the effects of bilateral infusions in the prelimbic cortex of d-cycloserine (DCS), a partial agonist of the NMDA receptor-associated glycine site. Wistar rats underwent a training session (acquisition, three trials) and a 24-h test (two retention and two relearning trials) of a rapidly learned olfactory discrimination task. Rats infused with DCS (10 μg/site) prior to training exhibited a significant enhancement of performance in such odor-reward task, especially in relearning.