کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4314063 | 1290021 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the CaV2.1α1 mutation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the CaV2.1α1 mutation Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the CaV2.1α1 mutation](/preview/png/4314063.png)
چکیده انگلیسی
Heterozygous rolling Nagoya (rol/+) mice carrying CaV2.1α1 mutation demonstrated normal behavior in Y maze test. Similar spontaneous alternation patterns were noted in wild-type and rol/+ mice injected with N-methyl-d-aspartate (NMDA; 0–50 mg/kg, sc). Systemic injection of NMDA receptor blocker (MK-801; 0.05 mg/kg, ip) or intrahippocampal injection of MK-801 (0.5 μg/side), which had no effect in wild-type controls, decreased spatial cognition in rol/+ mice. These results indicate that CaV2.1α1 mutation probably through decrease in Ca2+ influx lowers the threshold for learning impairment. The combination subthreshold pharmacological and genetic approach is useful to study functional pathways in neuronal circuits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 213, Issue 1, 12 November 2010, Pages 121–125
Journal: Behavioural Brain Research - Volume 213, Issue 1, 12 November 2010, Pages 121–125
نویسندگان
Eiki Takahashi, Kimie Niimi, Chitoshi Itakura,