Behavioural deterioration induced by intrahippocampal NAC61–95 injections and attenuation with ibuprofen

Pre-aggregated non-amyloid component of α-synuclein, NAC61–95, was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n = 6 per group), subgroups were treated orally with either ibuprofen (40 mg/kg) or vehicle (10% sucrose) twice daily. Intrahippocampal injection of NAC61–95 increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.