کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4314916 | 1290054 | 2008 | 8 صفحه PDF | دانلود رایگان |
The serotonin 1A (5-HT1A)-receptor is involved in a wide range of physiological functions, but has also been implicated in the pathophysiology of anxiety disorders and depression. Although the 5-HT1A-receptor is one of the best described receptor subtypes of the serotonergic system, its complex distribution pattern, pre- and postsynaptic localisation, and its impact on various neurotransmitters aggravate the attribution of 5-HT1A-agonistic effects to behavioural outcomes. The role of 5-HT1A-receptors for cognitive processes seems undisputed. However, the exact involvement of pre- and postsynaptic sites remains unexplained.Genetically modified animals are a complementary approach to pharmacological studies for further investigations of the role of the 5-HT1A-receptor. Next to 5-HT1A-receptor knockout mice, two transgenic mouse lines exist that either overexpress the 5-HT1A-receptor transiently or permanently. The latter mouse line stands out due to the fact that a distinct overexpression is primarily found in the outer cortical layers and hippocampus, both projection areas of serotonergic neurons. Here, we discuss the findings obtained from 5-HT1A-receptor knockout and overexpressing mice concerning their learning and memory abilities.
Journal: Behavioural Brain Research - Volume 195, Issue 1, 16 December 2008, Pages 78–85