کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4315658 | 1290089 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlation between phosphorylation level of a hippocampal 86Â kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Correlation between phosphorylation level of a hippocampal 86Â kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome Correlation between phosphorylation level of a hippocampal 86Â kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome](/preview/png/4315658.png)
چکیده انگلیسی
The effects of chronic ethanol and thiamine deficiency, alone or associated, on hippocampal protein phosphorylation profiles ranging in molecular weight from 30 to 250Â kDa molecular weight, in stimulated (high K+ concentration) and unstimulated (basal) conditions were investigated. These treatments significantly changed the phosphorylation level of an 86Â kDa phosphoprotein. Thiamine deficiency, but not chronic ethanol, induced a decrease in a behavioural extinction index, which is significantly correlated to the phosphorylation level of the p86 protein. These data add to and extend previous findings by our laboratory implicating the involvement of hippocampal neurotransmission components in extinction of a behaviour which involves learning of environmental spatial cues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 180, Issue 1, 4 June 2007, Pages 102-106
Journal: Behavioural Brain Research - Volume 180, Issue 1, 4 June 2007, Pages 102-106
نویسندگان
Rita G.W. Pires, SÃlvia R.C. Pereira, Fabiana M. Carvalho, Ieda F. Oliveira-Silva, Vany P Ferraz, Angela M. Ribeiro,