کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4316080 | 1290106 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Olanzapine differentially affects 5-HT2A and 2C receptor mRNA expression in the rat brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Olanzapine differentially affects 5-HT2A and 2C receptor mRNA expression in the rat brain Olanzapine differentially affects 5-HT2A and 2C receptor mRNA expression in the rat brain](/preview/png/4316080.png)
چکیده انگلیسی
This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 171, Issue 2, 10 August 2006, Pages 355–362
Journal: Behavioural Brain Research - Volume 171, Issue 2, 10 August 2006, Pages 355–362
نویسندگان
Xu-Feng Huang, Mei Han, Xin Huang, Katerina Zavitsanou, Chao Deng,