کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4316497 1613105 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toward an integrative science of the developing human mind and brain: Focus on the developing cortex
ترجمه فارسی عنوان
به علم یکپارچه ذهن و مغز انسان در حال توسعه: تمرکز بر قشر در حال رشد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی

Based on the Huttenlocher lecture, this article describes the need for a more integrative scientific paradigm for addressing important questions raised by key observations made over 2 decades ago. Among these are the early descriptions by Huttenlocher of variability in synaptic density in cortex of postmortem brains of children of different ages and the almost simultaneous reports of cortical volume reductions on MR imaging in children and adolescents. In spite of much progress in developmental neurobiology, developmental cognitive neuroscience, and behavioral and imaging genetics, we still do not know how these early observations relate to each other. It is argued that large scale, collaborative research programs are needed to establish the associations between behavioral differences among children and imaging biomarkers, and to link the latter to cellular changes in the developing brain. Examples of progress and challenges remaining are illustrated with data from the Pediatric Imaging, Neurocognition, and Genetics Project (PING).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Cognitive Neuroscience - Volume 18, April 2016, Pages 2–11
نویسندگان
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