کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4318773 1613239 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spinal cord injury affects I-wave facilitation in human motor cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Spinal cord injury affects I-wave facilitation in human motor cortex
چکیده انگلیسی


• I-wave facilitation is decreased in SCI patients with abnormal CMCT.
• I-wave interactions are increased in SCI patients with normal CMCT.
• Cortical excitability is increased in patients with preserved corticospinal projections.
• This TMS technique provides a useful assessment of cortical function after SCI.

Transcranial magnetic stimulation (TMS) is a useful non-invasive approach for studying cortical physiology. To further clarify the mechanisms of cortical reorganization after spinal cord injury (SCI), we used a non-invasive paired TMS protocol for the investigation of the corticospinal I-waves, the so-called I-wave facilitation, in eight patients with cervical SCI.We found that the pattern of I-wave facilitation significantly differs between SCI patients with normal and abnormal central motor conduction (CMCT), and healthy controls. The group with normal CMCT showed increased I-wave facilitation, while the group with abnormal CMCT showed lower I-wave facilitation compared to a control group. The facilitatory I-wave interaction occurs at the level of the motor cortex, and the mechanisms responsible for the production of I-waves are under control of GABA-related inhibition. Therefore, the findings of our small sample preliminary study provide further physiological evidence of increased motor cortical excitability in patients with preserved corticospinal projections. This is possibly due to decreased GABAergic intracortical inhibition. The excitability of networks producing short-interval intracortical facilitation could increase after SCI as a mechanism to enhance activation of residual corticospinal tract pathways and thus compensate for the impaired ability of the motor cortex to generate appropriate voluntary movements. Finally, the I-wave facilitation technique could be used in clinical neurorehabilitation as an additional method of assessing and monitoring function in SCI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 116, July 2015, Pages 93–97
نویسندگان
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