Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat

► For the first time experiments provide evidence for a interaction between calcitonin and capsaicin. ► Calcitonin reduces voltage activated calcium channel currents (VACCCs). ► Effects of calcitonin are voltage-dependent. ► Calcitonin and capsaicin have additive effects on VACCCs. ► Calcitonin abolishes voltage-dependent effects of capsaicin on VACCCs.