کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4319436 1290814 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glutamate responsiveness of medial vestibular nucleus neurons in aged rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Glutamate responsiveness of medial vestibular nucleus neurons in aged rats
چکیده انگلیسی
Disequilibrium, dizziness, vertigo and falls are vestibular system-related problems which are very common especially in older people. In order to clarify these age-related disorders one must understand first the age-related changes in the properties of vestibular neurons that are responsible for equilibrium. The responsiveness of medial vestibular nucleus (MVN) neurons to the NMDA and AMPA/kainate receptor agonists was investigated in slices prepared from young and aged rats using extracellular single cell recording techniques. In both young and aged rats bath application of NMDA and AMPA caused a reversible, dose-dependant increase in the spontaneous discharge of the MVN neurons. The excitatory effects of both NMDA and AMPA on the spontaneous activity of aged MVN neurons were similar to those of young MVN neurons. The spontaneous firing rates of the MVN cells were also similar in young and aged rats. These results suggest that the responsiveness of the NMDA and AMPA/kainate receptors and the excitability of the MVN neurons do not change with age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 81, Issue 1, 15 January 2010, Pages 81-84
نویسندگان
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