کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4319650 1290826 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Misexpression of miR-196a induces eye anomaly in Xenopus laevis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Misexpression of miR-196a induces eye anomaly in Xenopus laevis
چکیده انگلیسی

miR-196a is located in the posterior trunk and plays a role in limb development. Here we show that miR-196a is able to induce eye anomaly in Xenopus laevis. Microinjection of synthetic miRNA precursor molecule for mammalian miR-196a into Xenopus embryo is sufficient for miR-196a overexpression during early development. The misexpression of miR-196a in anterior embryo led to dose-dependent eye anomalies, especially size reduction. In addition, the expression of ET, Rx1, Six3, Pax6, Lhx2, Optx2 and Ath5 in eye field or optic cup was also down-regulated. These results indicate that miR-196a can target gene(s) in the genetic network involved in eye formation, providing a potential tool for studying the mechanisms of eye development and diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 79, Issue 1, 6 April 2009, Pages 26–31
نویسندگان
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