کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319739 | 1290829 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of carbenoxolone on hippocampal formation theta rhythm in rats: In vitro and in vivo approaches
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effect of carbenoxolone on hippocampal formation theta rhythm in rats: In vitro and in vivo approaches The effect of carbenoxolone on hippocampal formation theta rhythm in rats: In vitro and in vivo approaches](/preview/png/4319739.png)
چکیده انگلیسی
The role of gap junction (GJ) coupling in the generation of hippocampal formation theta rhythm was investigated in vitro, with use of brain slices, and in vivo, with use of urethane anesthetized rats. Carbenoxolone, the succinyl ester of glycyrrhetinic acid, and GJ blocker reversibly abolished hippocampal formation theta rhythm recorded in slice preparations and urethane anesthetized rats. The present study yielded novel data which demonstrated that the pattern of delay in blockage of theta rhythm after carbenoxolone treatment, and the pattern of theta recovery after administration of this agent, require a specific time period (2–3 h for delay and 8–12 h for recovery), one that can be demonstrated using different experimental protocols.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 78, Issue 6, 30 March 2009, Pages 290–298
Journal: Brain Research Bulletin - Volume 78, Issue 6, 30 March 2009, Pages 290–298
نویسندگان
Renata Bocian, Anna Posłuszny, Tomasz Kowalczyk, Henryk Gołębiewski, Jan Konopacki,