کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4320110 | 1613296 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mismatch negativity analysis in drug-resistant epileptic patients implanted with vagus nerve stimulator Mismatch negativity analysis in drug-resistant epileptic patients implanted with vagus nerve stimulator](/preview/png/4320110.png)
It is well known that some epileptic patients does not respond to conventional treatments, despite multiple combination of antiepileptic drugs, and they are therefore considered drug-resistant. For these patients, vagal nerve stimulation (VNS) represents a successful alternative to traditional therapy, and it is generally well tolerated; beside benefits on seizure frequency, VNS showed positive effects on cognition and mood. Aim of this study was to investigate short-term memory changes in a group of 12 patients implanted with VNS, through Mismatch Negativity wave (MMN). After 1 year of follow-up, MMN latencies and amplitudes did not show significant changes following VNS implantation, independently on current intensity, as compared with pre-implantation values. In two patients, MMN values, which were abnormal before VNS implantation, showed a major reduction in latency and an increase in amplitude after implantation, suggesting a likely positive effect of VNS on pre-attentive processes investigated by MMN.
Journal: Brain Research Bulletin - Volume 73, Issues 1–3, 15 June 2007, Pages 81–85