کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4320176 1613295 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
5-HT2A receptors are differentially expressed in bullfrog and rat retinas: A comparative study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
5-HT2A receptors are differentially expressed in bullfrog and rat retinas: A comparative study
چکیده انگلیسی

Expression of 5-hydroxytryptamine (5-HT) 2A receptor (5-HT2A) was studied in bullfrog and rat retinas by immunocytochemistry. In the bullfrog retina, 5-HT2A-immunoreactivity was observed in both the outer and inner plexiform layers (OPL and IPL). Double labeling experiments further showed that 5-HT2A was expressed in Müller cells stained by GFAP. Labeling for 5-HT2A was strong in the somata and endfeet and relatively weak in the major processes and fine branchets of Müller cells. In contrast, 5-HT2A immunoreactivity was hardly detected in the rat retina, and no rat Müller cells were labeled. Furthermore, immunocytochemical assay demonstrated that labeling for 5-HT was present in amacrine cells and displaced amacrine cells in the inner retina of bullfrog, but not in the rat retina. These results suggest that 5-HT may modulate retinal information processing via activating 5-HT2A expressed in neuronal and glial elements in bullfrog, but that such modulation is unlikely to occur in rat.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 73, Issues 4–6, 12 July 2007, Pages 273–277
نویسندگان
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