کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4320235 1613299 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
OFF response of bullfrog cones is shaped by terminal ionotropic GABA receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
OFF response of bullfrog cones is shaped by terminal ionotropic GABA receptors
چکیده انگلیسی

We recently reported an ionotropic GABA receptor expressed at the bullfrog retinal cone terminal that is potentiated by the GABAA receptor antagonist bicuculline (BIC) and suppressed by the GABAC receptor antagonist imidazole-4-acetic acid (I4AA) [13]. In this study, by using the patch clamp technique in current clamp mode, we show that activation of this GABA receptor causes voltage changes of cones, which are closely dependent on the membrane potential level in relation to the chloride equilibrium potential of the cells. Furthermore, the OFF overshoot of cone light responses is enhanced or diminished when this receptor is potentiated by BIC or suppressed by I4AA, suggesting the involvement of this GABA receptor in shaping OFF light responses of bullfrog cones.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 71, Issues 1–3, 11 December 2006, Pages 219–223
نویسندگان
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