کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4320252 | 1290855 | 2006 | 7 صفحه PDF | دانلود رایگان |
The Bcl-2 family of proteins has been characterized as a key regulator of cell death programs. In addition, these proteins also play important roles in cellular differentiation, such as axonal growth. The role of Bcl-2 family members on axonal regeneration and neurite extension has been controversial so far. Here, we examine the influence of Bcl-xL on axonal regeneration from adult retina explants in vitro. We delivered recombinant Bcl-xL into retinal tissue, mediated by the Tat-protein transduction domain, and observed its effect on retinal axon extension. We found that Bcl-xL increased the number of regenerating neurites, but did not increase their length. Our results indicate that Bcl-xL stimulates axonal initiation but not axonal elongation after crush injury to retinal explants, without altering the number of surviving neurons.
Journal: Brain Research Bulletin - Volume 70, Issue 2, 30 June 2006, Pages 117–123