Effect of topiramate and traditional antiepileptic drugs on pituitary-sexual gland axis in adult males with epilepsy*

Both new and traditional antiepileptic drugs have a certain effect on pituitary-sexual gland axis. In addition, a short-term application (about 6 months) of topiramate can mainly influence on pituitary hormone (LH and PRL). Valproic acid has an obvious effect on FSH and carbamazepine also has a certain effect on LH.