کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4320662 1291518 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons
ترجمه فارسی عنوان
ادغام دندریتیک دیفرانسیل پتانسیل های سیناپتیک و کلسیم در اینترنورونهای سرابی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Large, fast dendritic EPSPs favor sublinear integration, but not channel activation
• Supralinear dendritic [Ca2+] integration is concomitant with sublinear integration
• Supralinear [Ca2+] integration drives a transient, local synaptic plasticity

SummaryDendritic voltage integration determines the transformation of synaptic inputs into output firing, while synaptic calcium integration drives plasticity mechanisms thought to underlie memory storage. Dendritic calcium integration has been shown to follow the same synaptic input-output relationship as dendritic voltage, but whether similar operations apply to neurons exhibiting sublinear voltage integration is unknown. We examined the properties and cellular mechanisms of these dendritic operations in cerebellar molecular layer interneurons using dendritic voltage and calcium imaging, in combination with synaptic stimulation or glutamate uncaging. We show that, while synaptic potentials summate sublinearly, concomitant dendritic calcium signals summate either linearly or supralinearly depending on the number of synapses activated. The supralinear dendritic calcium triggers a branch-specific, short-term suppression of neurotransmitter release that alters the pattern of synaptic activation. Thus, differential voltage and calcium integration permits dynamic regulation of neuronal input-output transformations without altering intrinsic nonlinear integration mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 91, Issue 4, 17 August 2016, Pages 837–850
نویسندگان
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