Intercellular cross-talk in intracerebral hemorrhage

• Recent studies have elucidated many potential injury pathways after ICH.
• Various hematoma- and cell–cell interactions play a role in ICH-related injury.
• Such interactions are also important in regulating hematoma resolution.
• We summarize recent advances in ICH research focusing on intercellular cross-talk.

Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high mortality and morbidity. Currently, there are few treatment strategies for ICH-induced brain injury. A recent increase in interest in the pathophysiology of ICH has led to elucidation of the pathways underlying ICH-induced brain injury, pathways where intercellular and hematoma to cell signaling play important roles. In this review, we summarize recent advances in ICH research focusing on intercellular and hematoma:cell cross-talk related to brain injury and recovery after ICH.This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.