کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4324133 1613859 2014 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
ترجمه فارسی عنوان
سیستم های اکسی توسین و وازوپرسین در سندرم های ژنتیکی و اختلالات توسعه ی عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی

Oxytocin (OT) and arginine vasopressin (AVP) are two small, related neuropeptide hormones found in many mammalian species, including humans. Dysregulation of these neuropeptides have been associated with changes in behavior, especially social interactions. We review how the OT and AVP systems have been investigated in Autism Spectrum Disorder (ASD), Prader–Willi Syndrome (PWS), Williams Syndrome (WS) and Fragile X syndrome (FXS). All of these neurodevelopmental disorders (NDD) are marked by social deficits. While PWS, WS and FXS have identified genetic mutations, ASD stems from multiple genes with complex interactions. Animal models of NDD are invaluable for studying the role and relatedness of OT and AVP in the developing brain. We present data from a FXS mouse model affecting the fragile X mental retardation 1 (Fmr1) gene, resulting in decreased OT and AVP staining cells in some brain regions. Reviewing the research about OT and AVP in these NDD suggests that altered OT pathways may be downstream from different etiological factors and perturbations in development. This has implications for ongoing studies of the therapeutic application of OT in NDD.This article is part of a Special Issue entitled Oxytocin and Social Behav.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1580, 11 September 2014, Pages 199–218
نویسندگان
, , , , , ,