کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4324221 1613868 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in the adult HPA axis and affective behaviors are altered by perinatal exposure to a low dose of bisphenol A
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Sex differences in the adult HPA axis and affective behaviors are altered by perinatal exposure to a low dose of bisphenol A
چکیده انگلیسی


• The perinatal BPA exposure alters the sex differences in affective behaviors.
• The activity of HPA-axis is depressed in female BPA-rats and is enhanced in male BPA-rats.
• MR-induced nNOS–CREB signaling is depressed in male BPA-rats.
• Serum testosterone level is reduced in male BPA-rats.

Bisphenol A (BPA), an estrogen-mimicking endocrine disrupter, when administered perinatally can affect affective behaviors in adult rodents, however the underlying mechanisms remain largely unclear. Postnatal day (PND) 80 vehicle-injected control female rats showed more obvious depression- and anxiety-like behaviors than males, indicative of sexually dimorphic affective behaviors. When female breeders were subcutaneously injected with BPA (2 µg/kg) from gestation day 10 to lactation day 7, sex difference of affective behaviors was impaired in their offspring (PND80 BPA-rats), as results that female BPA-rats showed a visible “antianxiety-like” behavior, and male BPA-rats increased depression-like behavior compared to vehicle-injected controls. Notably, basal levels of serum corticosterone and adrenocorticotropin (ACTH), and corticotropin-releasing hormone mRNA were increased in male BPA-rats, but not in female BPA-rats, in comparison with vehicle-injected controls. Following mild-stressor the elevation of corticosterone or ACTH levels was higher in male BPA-rats, whereas it was lower in female BPA-rats than vehicle-injected controls. In comparison with vehicle-injected controls, the level of glucocorticoid receptor (GR) mRNA in hippocampus or hypothalamic paraventricular nucleus was increased in female BPA-rats, while decreased in male BPA-rats. In addition, the levels of hippocampal mineralocorticoid receptor (MR) mRNA, neuronal nitric oxide synthase (nNOS) and phospho-cAMP response element binding protein (p-CREB) were increased in female BPA-rats, but were decreased in male BPA-rats. Furthermore, the testosterone level was reduced in male BPA-rats. The results indicate that the perinatal exposure to BPA through altering the GR and MR expression disrupts the GR-mediated feedback of hypothalamic–pituitary–adrenal (HPA) axis and MR-induced nNOS–CREB signaling, which alters sex difference in affective behaviors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1571, 7 July 2014, Pages 12–24
نویسندگان
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