کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4324460 | 1613898 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NBGAMPKGoto-KakizakiMCAOECAAMPtPATTC2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chlorideAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استI/R - I / Radenosine monophosphate - آدنوزین مونوفسفرهmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیInfarct - انفارکتischemia/reperfusion - ایسکمی / رپرفیوژنDiabetes - بیماری قندanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancehemorrhagic transformation - تحول هموراژیکstandard error of the mean - خطای استاندارد میانگینBBB - سد خونی مغزیIschemic stroke - سکته مغزی ایسکمیکexternal carotid artery - شریان کاروتید خارجیtissue plasminogen activator - فعال کننده بافتی پلاسمینوژنBlood-brain barrier - مانع خون مغزیMetformin - متفورمینSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیMET - ملاقات کردEdema - ورمStair - پلهPolyethylene - پلی اتیلن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Diabetes worsens functional outcome and is associated with greater hemorrhagic transformation (HT) after ischemic stroke. We have shown that diabetic Goto-Kakizaki (GK) rats develop greater HT and neurological deficit despite smaller infarcts after transient middle cerebral artery occlusion (MCAO) with the suture model. However, the impact of (1) the duration of ischemia/reperfusion (I/R); (2) the method of ischemia; and (3) acute glycemic control on neurovascular injury and functional outcome in diabetic stroke remained unanswered. Wistar and GK rats were subjected to variable MCAO by suture or embolus occlusion. A group of GK rats were treated with insulin or metformin before stroke with suture occlusion. In all groups, infarct size, edema, HT occurrence and severity, and functional outcome were measured. Infarct size at 24Â h was smaller in GK rats with both suture and embolic MCAO, but expanded with longer reperfusion period. Edema and HT were increased in GK rats after 90Â min and 3Â h occlusion with the suture model, but not in the embolic MCAO. Neurological deficit was greater in diabetic rats. These findings suggest that diabetes accelerates the development of HT and amplifies vascular damage in the suture model where blood flow is rapidly reestablished. Acute metformin treatment worsened the infarct size, HT, and behavior outcome, whereas insulin treatment showed a protective effect. These results suggest that the impact of ischemia/reperfusion on neurovascular injury and functional outcome especially in disease models needs to be fully characterized using different models of stroke to model the human condition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1541, 6 December 2013, Pages 106-114
Journal: Brain Research - Volume 1541, 6 December 2013, Pages 106-114
نویسندگان
Weiguo Li, Zhi Qu, Roshini Prakash, Connie Chung, Handong Ma, Md Nasrul Hoda, Susan C. Fagan, Adviye Ergul,